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WE STUDY THE CELL TYPES AND CELL STATES UNDERLYING CHRONIC PAIN AND HEADACHE

Animal models of pain at single-cell resolution

Characterizing cell-type-specific molecular adaptations in animal models of chronic pain and headache.

Cell atlas of human sensory neurons

We are building single-cell gene expression datasets of human trigeminal and dorsal root ganglia

EPIGENOMIC mechanisms of nerve regeneration

Axonal injury initiates a transcriptional metamorphosis of sensory neurons into cells focused on regeneration. We are studying the epigenetic mechanisms that mediate this dramatic transformation.

next-generation pain therapeutics

Using single-cell genomics, we are characterizing nociceptor-specific molecular features that can be targeted for the development of highly-selective pain therapeutics.

HUMAN AND MOUSE TRIGEMINAL GANGLION CELL ATLAS

TG paper graphic abstract

EXPLORE PAIN BIOLOGY AT SINGLE-CELL RESOLUTION

PUBLICATIONS

view our latest research on bioRxiv
view our publications on PubMed

MEET THE TEAM

WILLIAM RENTHAL, M.D., PH.D.

PRINCIPAL INVESTIGATOR

Will is the Director of Headache Research at the John R. Graham Headache Center. He earned his M.D. and Ph.D. at the UT Southwestern Medical Center and completed his neurology training at UT Southwestern and Brigham and Women’s Hospital. He trained with Dr. Eric Nestler (doctoral) and Dr. Michael Greenberg (postdoctoral).

Shamsuddin bhuiyan, pH.D.

POSTDOCTORAL FELLOW
 

Shams uses computational approaches and mathematical models to understand gene expression changes after peripheral nerve injury. Prior to joining the Renthal lab, Shams completed his PhD in Bioinformatics at the University of British Columbia with Dr. Paul Pavlidis.

HYO JEONG YONG, PH.D.

POSTDOCTORAL FELLOW

Hyo is studying the function of nociceptor-specific gene expression. She received her M.S. from Macquarie University and her Ph.D. from Korea University with Dr. Jae Young Seon,

EVANGELIA SEMIZOGLOU, PH.D.

POSTDOCTORAL FELLOW

Eva is studying trigeminal ganglion cell types and their function. She received her Ph.D. at Kings College London with Drs. David Andersson and Stuart Bevan. 
 

ERIKA WILLIAMS, MD., PH.D.

RESEARCH FELLOW

Erika is studying the cell types of human sensory ganglia and attends as a neuromuscular specialist. She received her M.D. and Ph.D.  degrees from Harvard Medical School where she studied the vagus  with  Dr. Steve Liberles. She then completed her neurology residency and neuromuscular fellowship at Mass General Brigham.  
 
Dustin

DUSTIN GRIESEMER, M.D., PH.D.

RESEARCH FELLOW

Dustin is studying gene regulation in human sensory ganglia and is a PGY4 anesthesia resident here at BWH. He received his M.D. and Ph.D. degrees from Harvard Medical School where he studied the function of genetic variation in 3’UTRs with Dr. Pardis Sabeti.

LILY HE, PH.D

POSTDOCTORATE FELLOW

Lily is studying gene regulation in sensory neurons and is interested in developing cell-type specific gene therapies to treat pain. She completed her Ph.D. in Neuroscience at Harvard University with Dr. Nicholas Bellono.

JIAXIANG WANG, M.S.

RESEARCH SCIENTIST

Jiaxiang is a research scientist and studies gene regulation in sensory neurons. He received his bachelors degree in Neurobiology at UC Davis and his master’s degree in Biotechnology at Brandeis University. 

PARTH BHATIA, M.S.

RESEARCH SCIENTIST

Parth is a research scientist and studies gene regulation in sensory neurons. He received his bachelors degree at Jamie Hamdard University and his masters degree in human genetics at the University of Maryland. 

 

ahmed morsi, b.s.

RESEARCH SCIENTIST

Ahmed is a research scientist and studies molecular features of nociceptors. He received his bachelors degree from Berkeley. 

 

QIYI LI, M.S.

RESEARCH SCIENTIST

Qiyi is a research scientist and studies the trigeminal ganglion. He received his bachelors degree at Shenyang Pharmaceutical University and his masters degree in Pharmacology from Tufts University. 

Jay Luo

UNDERGRADUATE STUDENT

Jay is an undergraduate student at Johns Hopkins University where he is majoring in neuroscience. He is working on mechanisms of nociceptor-specific gene expression.  

Evangeline glimer

UNDERGRATUATE STUDENT

AARON BROWN

ADMINISTRATION

SUZANNE SZAK

PROJECT MANAGER

ALUMNI

Angeliki Vgontzas, M.D.
Research fellow (2018-2020)
Current: Assistant Professor of Neurology, Brigham And Women’s Hospital/Harvard Medical School

Lite Yang, B.S.
Research Assistant (2018-2021)
Current: Graduate student, Washington University St. Louis

Matas Vitkauskas
Summer student (2021)
Current: Undergraduate student, YaleNUS College

Mengyi Xu, B.S.
Research Assistant (2020-2022)
Current: Graduate student, McGill University

Jia Li, Ph.D.
Fellow 2021-2023

Jay Luo
Undergraduate student (2022-2023)
Current: Graduate student, Harvard University

Katerina Pantaleo
Undergraduate student (2022-2024)
Current: Nursing student at University of Saint Joseph

NEWS AND PHOTOS

CONTACT

We are recruiting graduate students, postdoctoral fellows, and research assistants!

To apply, please email wrenthal@bwh.harvard.edu:

Your CV and the names of three references

SUPPORT

If you are interested in supporting our research, please contact Ginny Fuller Marinaro 

@willrenthal

© 2023 Renthal  Lab